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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Downregulation of the glucose transporter GLUT 1 in the cerebral microvasculature contributes to postoperative neurocognitive disorders in aged mice

Fig. 5

The metabolic profiles after GLUT1 overexpression in postsurgical aged mice. A Heatmap of metabolites in the postsurgical hippocampus on POD 14. B PLSDA score plot. C VIP scores of PLSDA model. D-G Histogram showing relative changes in ATP (D); adenosine (E); glyceraldehyde-3P (F); and glucose (G); Student’s t test with n = 3 mice per group. Data presented as mean ± SEM, *P < 0.05. PLSDA: Partial least squares discriminant analysis. VIP scores: variable of importance scores. P, phosphate; LAP,  laparotomy; AAV9-ICAM2-CON,  AAV9 control viral vector with ICAM2 promoter and GFP sequence; AAV9-ICAM2-GLUT1 or AAV9-GLUT1,  GLUT1 sequence was inserted into AAV9 control viral vector after ICAM2 promoter and followed by GFP sequence

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Journal of Neuroinflammation

ISSN: 1742-2094