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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency

Fig. 9

GO enrichment analysis of the association network between gene targets in the hypothalamus and adrenal glands after T3-SCI. (A, B) (A) Targets of upregulated genes associated with enriched GO pathways in the hypothalamus after T3-SCI. B Expression of the top 20 hub genes most closely associated with the GO pathways (in TPM). (C, D) C Targets of downregulated genes associated with enriched GO pathways in the hypothalamus after T3-SCI. D Expression of the top 20 hub genes most closely associated with the GO pathways (in TPM). (E–F) E Targets of upregulated genes associated with enriched GO pathways in the adrenal glands after T3-SCI. F Expression of the top 20 hub genes most closely associated with the GO pathways (in TPM). (G, H) G Targets of downregulated genes associated with the enriched GO pathways in the hypothalamus after T3-SCI. H Expression of the top 20 hub genes most closely associated with the GO pathways (in TPM). The T3-SCI group compared to the sham group: *p < 0.05, **p < 0.01, ***p < 0.001; the T3-SCI group compared to the T10-SCI group: #p < 0.05, ##p < 0.01, ###p < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094