Fig. 1

Flowchart illustrating the number of papers identified through database searching and other relevant sources, the number of full text articles screened, assessed, and excluded, and the final number of original papers surveyed. Publications that used more than one paradigm of encephalopathy or multiple treatment regimens were further subdivided if outcomes differed according to experimental paradigm or treatment regimen. After subdividing these publications there was a total of 59 individual studies. The studies are summarised in Table 1