A systematic review of immune-based interventions for perinatal neuroprotection: closing the gap between animal studies and human trials

Kelly, Sharmony B.; Tran, Nhi T.; Polglase, Graeme R.; Hunt, Rodney W.; Nold, Marcel F.; Nold-Petry, Claudia A.; Olson, David M.; Chemtob, Sylvain; Lodygensky, Gregory A.; Robertson, Sarah A.; Gunn, Alistair J.; Galinsky, Robert

doi:10.1186/s12974-023-02911-w

Journal of Neuroinflammation

Table 3 SYRCLE risk of bias assessment for included studies

From: A systematic review of immune-based interventions for perinatal neuroprotection: closing the gap between animal studies and human trials

References	Selection bias			Performance bias		Detection bias		Attrition bias	Reporting bias	Free from other bias?
References	Random sequence generation	Groups similar at baseline	Allocation concealment	Animals random housing	Blinding of caregivers and/or examiners	Random outcome assessment	Blinding of outcome assessor	Incomplete outcome data addressed	Free from selective outcome reporting	Free from other bias?
[61]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Yes	Unclear	Yes	No
[54]	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Unclear	Yes	No
[63]	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Yes
[62]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Yes
[43]	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Yes	Unclear	Yes	Yes
[44]	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[64]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[65]	Unclear	Unclear	Yes	Unclear	Unclear	Yes	Unclear	Yes	Yes	Yes
[66]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes
[67]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Yes	Unclear	Yes	Yes
[41]	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[42]	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[58]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Yes	Unclear	Yes	Yes
[68]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes
[57]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Yes	Unclear	Yes	Yes
[59]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Yes
[47]	Yes	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Yes
[48]	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Unclear	Yes	No
[70]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes
[37]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes
[71]	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Unclear	Yes	Yes
[60]	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Unclear	Yes	No
[72]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes
[73]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[74]	Yes	Unclear	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[45]	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[75]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes
[53]	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Yes
[76]	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes
[77]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[52]	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Yes
[56]	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[40]	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[49]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	No
[50]	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[46]	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes
[51]	Unclear	Unclear	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes
[39]	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes
[38]	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Yes	Unclear	Yes	Yes
[55]	Unclear	Yes	Yes	Unclear	Unclear	Unclear	Yes	Yes	Yes	Yes

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ISSN: 1742-2094

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