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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Nisin a probiotic bacteriocin mitigates brain microbiome dysbiosis and Alzheimer’s disease-like neuroinflammation triggered by periodontal disease

Fig. 2

Analysis of microbial community composition and diversity shows that nisin alters microbial diversity and community structure in brain following oral polymicrobial infection. The groups included Control, Infection, Nisin, Infection + Nisin. A–C Chao1 estimator, Shannon index and Simpson index are analyzed based on the numbers of OTUs from brain tissues. There is no significant difference in Chao1 among the four groups. As for Shannon index and Simpson index, the bacterial diversity score of the Infection + Nisin group is significantly lower than that of the Control, Infection and Nisin group. D PCoA based on weighted Unifrac distance is shown for different groups. The microbial compositions of Infection and Infection + Nisin group are shifting to different states, while the microbial compositions of Control and Nisin group are in the middle state. E Analysis of Similarity (Anosim) among different groups are shown. The microbiome compositions of the Control, Nisin and Infection + Nisin group are significantly different from that of the Infection group

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Journal of Neuroinflammation

ISSN: 1742-2094