Fig. 4

Persistent increase in Ki-67 + cells in the dorsal and ventral SGZ of males following r-mTBI. A Representative images of the dorsal SGZ (white dotted line) for Sham and r-mTBI animals at PID1 and PID3 in males and females. Contra (middle column) and ipsi (right column) SGZs with Ki-67 + ve cells are shown. B, C At PID1, r-mTBI males showed an increase in Ki-67 + cells in the dorsal DG (B) and ventral DG (C). This increase was seen in the contra- and ipsi-SGZ for r-mTBI males, but not in either hemisphere in r-mTBI females. D, E This increase in Ki-67 + cells was also observed at PID3 in the dorsal and ventral SGZ of r-mTBI males. Females did not show any significant difference in Ki-67 + cell numbers at PID3. Images were taken at 10 × and 40 ×; scale bars are 50 µm and 25 µm, respectively. Data presented as mean ± SEM. Open circles in bar graphs represent individual animal data points