Fig. 2

CD13 impedes acute stroke recovery and promotes neutrophil trans-migration. A No gross anatomical difference in large blood vessels between wild-type and CD13KO naïve mice (n = 3). B Smaller infarcts (n = 5–6/group) and C lower NDS (n = 10–11/group) in CD13KO compared to WT after MCAO. D No difference in cerebral blood flow between CD13 wild type and CD13 knockout (n = 3). E Higher microglia counts in the ipsilateral hemisphere of CD13KO mice after stroke. F No difference in the infiltrated monocytes in the ipsilateral hemisphere of CD13KO versus WT mice. G A decrease in ipsilateral infiltrated neutrophils in the CD13KO mice compared to the WT. n = 5–6/gp. Data presented as mean ± SEM. Two-group comparisons were analyzed by unpaired t-test with Welch’s correction. NDS analyzed by Mann–Whitney test and presented as a median with an interquartile range. Two-way ANOVA with Tukey’s multiple comparisons test was used to analyze flow cytometry data (*p < 0.05, **p < 0.01, ***p < 0.001)