Fig. 6
From: Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS
Mertk cKO animals display dysregulated OPC/OL dynamics during cuprizone-mediated demyelination. A Representative immunostaining of the corpus callosum from Mertk WT and cKO animals following 3 and 5 weeks cuprizone-challenge. Hoechst-labelled nuclei in cyan. Scale bar represents 50 µm. Inset scale bar represents 25 µm. B The density of Iba1+ve microglia was similar between Mertk WT and cKO mice. C The density of PDGFRα+ve OPCs was altered over the course of cuprizone-induced demyelination, with significantly more OPCs observed following 5 weeks demyelination. D A substantial reduction in CC1+ve oligodendrocytes was observed in the absence of microglial Mertk, although this did not reach statistical significance. Data obtained from n = 4 mice per group. Data represent means ± SD. Statistical significance was determined using two-way ANOVA with Fisher's LSD