Fig. 5
From: Impairing Gasdermin D-mediated pyroptosis is protective against retinal degeneration
WT and GsdmdI105N/I105N mice retinal RNA profiling, enrichment analysis and pathway analysis. A Volcano plot indicating top 20 differentially expressed genes in GsdmdI105N/I105N mice retinas compared to WT mice retina post-PD (adj.p.value < 0.1, N = 4–5). B Retinal cell types enriched in genes differentially expressed between GsdmdI105N/I105N and WT retinas post-PD (logFC < or > 1). C Illustration showcasing human and mouse cell types that express Gsdmd in the retina. D Biological processes that are positively and negatively enriched in GsdmdI105N/I105N compared to WT retinas post-PD (adj.p.value, N = 4 -5). Heatmaps showcasing downregulation in genes associated with E NF-κB regulated inflammation and F release of pro-inflammatory cytokines in GsdmdI105N/I105N mice retinas in comparison with WT mice retinas post-PD