Fig. 6

Multimodal sequencing of reclustered mononuclear phagocytes. A Reclustered mononuclear phagocytes on wnnUMAP. B Canonical marker genes are displayed for each cellular cluster in a dot plot. C The contribution of the experimental conditions to each cluster is visualized in the faceted wnnUMAP plot. The black arrow indicates the absence of the NC-mono cluster (green) from Nr4a1^−/− groups. D The distribution of cells within each experimental group is visualized with a stacked bar chart, including only macrophage and microglia clusters. E The contribution of the four experimental groups to each cluster is visualized with a stacked bar chart. Hypergeometric distribution analysis was performed to quantify if an experimental condition was significantly enriched in each cluster (asterisks). Asterisks are colored according to experimental condition and placed above a cluster if the enrichment test was significant at the α = 0.05 level after Bonferroni correction. Mac macrophage, MDM monocyte-derived macrophage, C-mono classical monocyte, NC-mono non-classical monocyte, cDC classical dendritic cell, pDC plasmacytoid dendritic cell, migDC migratory dendritic cell