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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Deletion of CD47 from Schwann cells and macrophages hastens myelin disruption/dismantling and scavenging in Schwann cells and augments myelin debris phagocytosis in macrophages

Fig. 1

Earlier and faster clearance of myelin debris in CD47−/− mice than in wild type mice. Myelin-specific protein MBP levels were determined in intact nerves and in Wallerian degenerating sciatic nerve segments from wild type (WT) and CD47−/− mice at the indicated days after surgery. Levels of myelin/MBP are presented as percentage of levels in intact nerves (time 0) normalized to 100%. Box and whisker plot of myelin/MBP levels in 4 to 17 different nerves at the indicated days after surgery are given. Significance of difference of WT mice from SIRPα−/− mice at the indicated days after surgery is ^p < 0.05 and ^^^p < 0.001, by two-way ANOVA and the Bonferroni multiple comparisons posttest. Significance of difference between levels of myelin/MBP in intact nerves (day 0) and those at the indicated days after surgery is *p < 0.05, **p < 0.001 and ***p < 0.0001, by one-way ANOVA and the Dunnett posttest calculated for each mouse strain separately

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Journal of Neuroinflammation

ISSN: 1742-2094