Fig. 2

Study design. A Reanalysis of previously published data for Bachstetter et al. [13] demonstrates the temporal pattern of IL-1β protein changes in the injured neocortex over time. Each circle represents an individual animal. The summary statistic shows the mean and standard deviation. B A graphic summary of the study design shows that the neocortex tissue was collected from the injured brain. RNA was isolated from the bulk tissue, and the samples were analyzed using the NanoString mouse Neuroinflammatory panel. C The study used wild-type (WT) and Interleukin-1 receptor-1 global knock-out (IL-1R1 gKO) mice at 3 h, 9 h, 24 h, and 72 h post-injury. Sham-injured mice were included at each post-injury time point. The number of male mice included at each time point is shown in the table. Data are plotted as mean ± SD