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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury

Fig. 3

Temporal pattern of neuroinflammatory-associated gene expression caused by a CHI in WT and IL-1R1 gKO mice. Volcano plots of injury-induced differential gene expression 3 h (A, E), 9 h (B, F), 24 h (C, G), and 72 h (D, H) post-injury. Data points above the reference line (grey) represent statistical significance (FDR < 0.05) using the NanoString analysis using a mouse Neuroinflammatory panel. Positive Mean Z-Score Difference (red dots) indicates higher gene expression relative sham mice. Negative Mean Z-Score Difference (blue dots) indicates lesser gene expression relative sham mice. The top left corner of each graph displays the total number of differentially expressed genes, with downregulated genes in blue and upregulated genes in red

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Journal of Neuroinflammation

ISSN: 1742-2094