Fig. 7

IL-1’s effect on chemokines at 3 h, 9 h, 24 h, and 72 h following a CHI in mice. The chemokine genes assessed include Ccl2, Ccl3, Ccl4. White groups indicate wild-type genotype. Yellow groups indicate IL-1R1 gKO genotype. Sham groups are a conglomeration of each respective genotype sham (WT sham or IL-1R1 gKO sham) at 3-, 9-, 24-, and 72-h post-sham procedure. Y-axis displays Z-score data for gene expression. X-axis indicates genotype and injury groups. Grey line indicates the reference line of the mean Z-score for combined WT and IL-1R1 gKO sham groups. To compare genes with significant effects in the two-way ANOVA (Table 1), post hoc tests were applied. A Dunnett's multiple comparison test was used to compare 3 h, 9 h, 24 h, and 72 h to the sham control group (^†p < 0.05, ^††p < 0.01, ^†††p = 0.001, ^††††p = 0.0001). The effect of genotype at each time point was compared using an unpaired two-tailed t-test (*p < 0.05, **p < 0.01, ***p = 0.001, ****p =< 0.0001)