IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury

Table 1 Two-way ANOVA of representative genes from pathway enrichment analysis

		Gene	Genotype	Injury	Interaction
Fig. 6	Astrocyte function	Amigo2	0.0013**	0.0209*	0.4594
		Fkbp5	0.0125*	< 0.001***	< 0.001***
		Lcn2	< 0.001***	< 0.001***	< 0.001***
		Slc6a1	< 0.001***	0.0122*	< 0.001***
	Microglia function	Cd68	< 0.001***	< 0.001***	0.2352
		P2ry12	0.0108*	< 0.001***	< 0.001***
		Tmem64	0.0024**	< 0.001***	0.0006***
		Trem2	0.1414	0.0036**	0.2985
	Neuron function	Bdnf	0.2514	0.0203*	< 0.001***
		Dlg1	0.3804	< 0.001***	0.0003***
		Grm3	0.1599	0.1842	0.0002***
		Homer1	0.6559	< 0.001***	0.0136*
Fig. 7	Chemokine	Ccl2	0.0197*	< 0.001***	0.0003***
		Ccl3	0.023*	< 0.001***	0.0057**
		Ccl4	0.0419*	< 0.001***	0.0002***
		Tnf	0.9953	0.0983	0.799

ISSN: 1742-2094