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Fig. 11 | Journal of Neuroinflammation

Fig. 11

From: Recombinant Slit2 suppresses neuroinflammation and Cdc42-mediated brain infiltration of peripheral immune cells via Robo1–srGAP1 pathway in a rat model of germinal matrix hemorrhage

Fig. 11

Brain Cdc42 activity assessment at 5 days after GMH. A There was an elevation of Cdc42 activity in brain after GMH, which reduced by recombinant Slit2 treatment. Recombinant Robo1 co-administration blocked the inhibition effect of recombinant Slit2 on brain Cdc42 activity. B srGAP1 siRNA, but not scrambled siRNA, blocked the inhibition effect of recombinant Slit2 on brain Cdc42 activity. N = 6/group. Mean ± SEM. ANOVA, Tukey. *P < 0.05 vs. Sham, #P < 0.05 vs. GMH + Vehicle, @P < 0.05 vs. GMH + rSlit2, &P < 0.05 vs. GMH + rSlit2 + srGAP1 siRNA

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Journal of Neuroinflammation

ISSN: 1742-2094