Skip to main content
Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Recombinant Slit2 suppresses neuroinflammation and Cdc42-mediated brain infiltration of peripheral immune cells via Robo1–srGAP1 pathway in a rat model of germinal matrix hemorrhage

Fig. 3

Effects of endogenous brain Slit2 knockdown in GMH. A Representative Western blotting image and quantitative analysis showed that Slit2 siRNA significantly reduced the brain Slit2 expression. Endogenous brain Slit2 knockdown worsened brain edema at 24 h after GMH (B) and aggravated neurobehavioral performance in the negative-geotaxis test (C) at 1 day and 2 days after GMH. D There was not significant different among all GMH groups in righting-reflex test during the 3 days after GMH. N = 6/group. Mean ± SEM. ANOVA, Tukey. *P < 0.05 vs. Sham, #P < 0.05 vs. GMH + Vehicle, &P < 0.05 vs. GMH + scrambled siRNA

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094