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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Recombinant Slit2 suppresses neuroinflammation and Cdc42-mediated brain infiltration of peripheral immune cells via Robo1–srGAP1 pathway in a rat model of germinal matrix hemorrhage

Fig. 4

Effects of recombinant Slit2 on neurobehavior after GMH. Recombinant Slit2 (10 μg/kg) improved the performance in the negative-geotaxis (A) and righting-reflex (B) at 1, 2 and 3 days after GMH. N = 6/group. *P < 0.05 compared to Sham, #P < 0.05 compared to GMH + Vehicle, rSlit2 (1 μg/kg), rSlit2 (3 μg/kg). C Brain Slit2 expression was increased in the rSlit2 treatment group, indicating that rSlit2 (10 μg/kg) was successfully delivered into the brain by intranasal administration. N = 4/group. Mean ± SEM. ANOVA, Tukey. *P < 0.05 vs. Sham, #P < 0.05 vs. GMH + Vehicle

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Journal of Neuroinflammation

ISSN: 1742-2094