Fig. 5

Peripheral EphA4 deficiency promotes P-ERK/P-Stat6/MERTK signaling. A–C mRNA expression of the efferocytosis receptor (MERTK, A) and its ligands (Gas6, B) and (Pros1, C) in the contralateral and ipsilateral cortex of WT^+WTBMCs and WT^+KOBMCs mice at 3dpi. N = 5–6 mice/group. Ns = non-significant; *P < 0.05; **P < 0.01; ***P < 0.001, ****P < 0.0001. Two-way ANOVA followed by Šídák’s multiple comparisons test. D Western blot analysis shows increased MERTK, ERK, and Stat6 phosphorylation in the ipsilateral cortex of chimeric WT^{+KO BMCs} mice. E–H Representative images showing peripheral-derived GFP + cells expressing MERTK (purple) and P-ERK (E, F) and P-Stat6 (G, H) in WT^{+WT BMCs} and WT^{+KO BMCs} mice. Scale bar = 50 µm in E, F, G, H and 10 µm in insets