Fig. 7

CTSS-induced Ephrin-B2 liberation accelerates sensory recovery. A Time course of HWT in IANX rats treated with rhCTSS + saline or rhCTSS + EBP. IANX + rhCTSS + saline (n = 7); IANX + rhCTSS + EBP (n = 5), Friedman test post hoc Dunn’s test, *P < 0.05, **P < 0.01 vs. day 2; GEE post hoc Bonferroni’s test. ^††P < 0.01. Boxes show the 25th–75th percentiles with the median value as a line within each box, and whiskers indicate the 10th and 90th percentiles of the data. All data points are shown in open circles. B Images showing FG-labeled TG neurons 14 day post-IANX. Column represents the average number of FG-labeled TG neurons out of total TG neurons. n = 5 in each, unpaired t test. ***P < 0.001. C Images show c-Jun and Hoechst-33258 immunofluorescence at the site of IAN injury 14 day post-IANX. Column represents the average number of c-Jun-positive cells at the injured site. n = 5 in each, unpaired t test. ***P < 0.001. Data represent the mean ± SEM in B and C. All data points are shown as open circles