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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast–Schwann cell-signaling relay

Fig. 8

Schematic illustration of the proposed model of axon regeneration at the site of IAN injury. M2 macrophages accumulate at the injured site post-IANX. M2 macrophages then release CTSS, which liberates Ephrin-B2 on fibroblasts. Ephrin-B2 then binds to EphB2 on SCs, inducing SCs to change into repair phenotype, subsequently facilitating axon regeneration

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Journal of Neuroinflammation

ISSN: 1742-2094