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Table 2 Prospective quantitative analysis of white blood cell subpopulations and C-reactive protein in stroke patients and controls

From: Temporal changes in regulatory T cell subsets defined by the transcription factor Helios in stroke and their potential role in stroke-associated infection: a prospective case–control study

 

Stroke D1

N = 52

Stroke D3

N = 52

Stroke D10

N = 51

Stroke D90

N = 33

Disease control group

N = 34

p D1 vs. DC

p D3 vs. DC

p D10 vs. DC

p D90 vs. DC

WBC × 103/µl

7.4

(5.8–10.6)

7.6

(5.7–10.2)

7.2

(5.9–8.1)

6.8

(5.6–7.7)

6.8

(5.7–8.4)

0.12

0.28

0.82

0.45

Lymphocytes × 103/µl

1.7 ± 0.9

2.0 ± 0.9

1.8 ± 0.7

1.9 ± 0.7

2.3 ± 1.2

0.008

0.01

0.02

0.07

Lymphocytes %

21.5 ± 11.6*

25.3 ± 10.9

25.8 ± 10.2

28 ± 7.5

31.3 ± 10

< 0.0001

0.02

0.03

0.16

Treg

(cells/μl)

13.2

(8.6–19.8)

15.4

(9.2–27.4)

12.9

(8.7–18.2)

14.5

(10.2–20.7)

16.4

(9.07–21.1)

0.61

0.62

0.42

0.91

Treg H+ 

(cells/μl)

8.0

(4.9–15.8)

9.1

(4.0–21.2)

6.1

(4.6–12.9)

9.4

(7.5–15.9)

13.8

(7.1–18.6)

0.03

0.04

0.03

0.27

Treg H−

(cells/μl)

4.6

(2.6–6.81)

4.7

(3.5–9.8)

5.3

(3.9–7.3)

4.3

(1.0–8.5)

1.0

(0.5–3.1)

< 0.0001

< 0.0001

< 0.0001

0.006

H−/H+ Treg ratio

0.5

(0.3–0.9)

0.6

(0.4–1.0)

0.6

(0.5–0.8)

0.2

(0.1–1.0)

0.05

(0.02–0.15)

< 0.0001

< 0.0001

< 0.0001

0.001

CRP, mg/L

4.2 (1.8–9.9)*

6.1 (2.1–22.1)*

3.8 (1.2–19.2)*

1.9 (0.4–5)

1.2 (0.6–2.2)

0.001

< 0.0001

0.03

0.23

  1. p-values in bold are statistically significant
  2. *Difference significant in relation to the value observed on D90 (p < 0.001). No other significant differences between D1-D3-D10-D90 were observed