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Table 3 Comparative characteristics of SAI+ and SAI− patients

From: Temporal changes in regulatory T cell subsets defined by the transcription factor Helios in stroke and their potential role in stroke-associated infection: a prospective case–control study

 

SAI+ N = 25

SAI− N = 27

p value

Age, years

73 ± 13

66 ± 12

0.24

Sex M/F, n

12/13

14/13

0.76/0.83

Time from stroke onset to blood sampling on D1, hours

18.5 (12–22)

17 (12–21)

0.57

CRP D1, mg/L

7.5 (6.1–27.5)

3.6 (1.3–6.4)

0.004

CRP D3

17.3 (7.9–69.5)

3.5 (1.2–6.5)

< 0.001

CRP D10

20.7 (2.8–45.1)

2.5 (1.3–5.1)

0.002

CRP D90

3.5 (1.4–5.3)

2.3 (1.1–3.8)

0.21

WBC D1, × 103/µl

10.6 ± 3.6

7.6 ± 2.5

< 0.0001

WBC D3

10.7 ± 5.3

6.8 ± 1.6

< 0.00001

WBC D10

9.1 ± 3.9

6.7 ± 1.5

0.002

WBC D90

7.1 ± 2.0

7.0 ± 0.9

0.63

Lymphocytes D1, × 103/µl

2.2 ± 1.1

1.8 ± 0.6

0.57

Lymphocytes D3

1.5 ± 0.8

2.4 ± 1.7

0.01

Lymphocytes D10

1.7 ± 0.9

1.9 ± 0.6

0.04

Lymphocytes D90

1.9 ± 0.8

1.9 ± 0.6

0.56

Lymphocytes D1, %

17.0 ± 10.2

25.4 ± 8.6

< 0.001

Lymphocytes D3

16.8 ± 6.9

27.7 ± 8.7

< 0.0001

Lymphocytes D10

19.1 ± 10.4

27.4 ± 8.7

0.006

Lymphocytes D90

27.1 ± 7.3

28.9 ± 8.4

0.91

H+ %Treg D1, %

73.7 (61.3–75.7)

69.4 (52.7–75.4)

0.76

H+ %Treg D3

76.6 (58.3–87.7)

58.8 (48.3–71.2)

0.03

H+ %Treg D10

59.6 (48.1–64.6)

65.1 (58.1–74.4)

0.11

H+ %Treg D90

88.7(64.1–99.8)

49.7 (43.0–89.4)

0.66

H+/H− D1

0.46 (0.3–1.3)

0.6 (0.37–0.9)

0.82

H+/H− D3

0.45 (0.15–0.85)

0.75 (0.4–1.3)

0.04

H+/H− D10

0.6 (0.5–0.8)

0.7 (0.5–1.1)

0.92

H+/H− D90

0.4 (0.11–1.2)

0.3 (0.1–1.0)

0.97

NIHSS D1, pts

9 (5–19)

3 (1–6)

0.001

NIHSS D3

13 (5–25)

2 (1–4)

< 0.001

NIHSS D10

13 (2–20)

1 (0–2)

< 0.001

NIHSS D90

4 (2–6)

1 (0–3)

0.15

mRS D3, pts

4 (1–5)

1 (0–3)

< 0.001

mRS D10

4 (1–5)

1 (0–2)

< 0.001

mRS D90

1 (0–3)

0 (0–1)

0.05

Stroke volume D1, mL

5.6 (0.2–25)

2.8 (0.5–9.5)

0.45

Stroke volume D90

1 (1–25)

1 (0.1–2.7)

0.76

  1. p-values in bold are statistically significant
  2. WBC—white blood cells; lymphocytes—percentage of lymphocytes in leukocyte population (automatic blood smear); Treg%CD3—percentage of Tregs in lymphocyte population (flow cytometry); H+ %Treg—percentage of Tregs with Helios expression in Treg population (flow cytometry); NIHSS—National Institutes of Health Scale Score; mRS—modified Rankin Scale score; D1, D3, D10, D90—days after stroke