Fig. 1
From: Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis
Microglial activation and attenuated hippocampal neurogenesis in DG were observed in depression model of mice. A Immunostaining with anti-Dcx and anti-NeuN of hippocampal coronal sections of mice under CUMS treatment. B The statistical analysis of Dcx+ cells located at the SGZ. The mice received CUMS treatment showed significantly decreased newborn, immature neurons as indicated by anti-Dcx staining (***p < 0.001 vs. Ctrl). C Immunostaining with anti-Iba1 of hippocampal coronal sections of mice under CUMS treatment. The mice received CUMS treatment showed increased Iba1+ signals in the DG, which might suggest increased numbers of reactive microglia. The experimental details are described in Additional file 1