Skip to main content
Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Design, synthesis, and characterization of novel system xC− transport inhibitors: inhibition of microglial glutamate release and neurotoxicity

Fig. 1

Design and scaffold of the first generation of prospective SxC− inhibitors. l-Tyr reflects the shape of a locked conformer of l-Glu but has no activity at SxC−. Halogenation of the aromatic ring of Tyr, followed by amidation of the molecule with a selection of acyl halides at 3,5-DBT's α-amino group allowed several chemical structures to be tested, varying in a branch of the scaffold hypothesized to interact with a hydrophobic pocket in the transporter

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094