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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Design, synthesis, and characterization of novel system xC− transport inhibitors: inhibition of microglial glutamate release and neurotoxicity

Fig. 5

35DPTA7 and 35DPTSA12 inhibit cystine uptake in microglia. Rat primary microglia were activated with 100 ng/ml LPS alone for 15 h, then the indicated concentrations of test substances were applied during application of selenocystine. After 30 min, uptake was stopped and assayed fluorometrically. Values are mean ± SEM of quadruplicate cultures. ****P < 0.0001 for all concentrations of 35DBTA7 vs. LPS alone; **P = 0.012 for 0.03 μM vs. 300 μM 35DBTA7, ***P = 0.0009 for 0.03 μM vs. 300 μM 35DBTSA12 (ANOVA and Bonferroni post hoc)

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Journal of Neuroinflammation

ISSN: 1742-2094