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Table 1 IC50 values of SxC- inhibitors

From: Design, synthesis, and characterization of novel system xC− transport inhibitors: inhibition of microglial glutamate release and neurotoxicity

Compound

IC50 ± SEM (μM)

3,5-DBT

3.490 ± 0.7788

35DBTA1

1.028 ± 0.4401

35DBTA2

5.793 ± 3.96

35DBTA3

0.1587 ± 0.0244

35DBTA5

25.48 ± 4.59

35DBTA6

N.D

35DBTA7

1.615 ± 0.3766

35DBTA8

0.1720 ± 0.0056

3,5-DIT

0.6647 ± 0.1265

2,5-DIH

N.D

35DBTSA12

0.9081 ± 0.3106

  1. Nonlinear regressions were performed in GraphPad Prism, which also provided IC50 ± SEM
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Journal of Neuroinflammation

ISSN: 1742-2094