Fig. 2From: The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female miceMetabolomics analysis of the hypothalamus from male and female mice with LPS-induced depressive-like behavior compared to their control counterparts. A 3D view of the OPLS-DA model showing four clearly separated groups, including saline-treated male controls (CON-Male, purple), LPS-treated depressive-like male mice (LPS-Male, green), saline-treated female controls (CON-Female, blue), and LPS-treated depressive-like female mice (LPS-Female, turquoise). B The OPLS–DA model shows a more noticeable separation between t each group pair. The colours correspond to those in (A). C The permutation test suggests the validity of the OPLS–DA model between each group pair, as the Q2 and R2 values yielded by the permutation test were higher than their original valuesBack to article page