Fig. 2

Central GPR120 agonism reduces LPS-induced hypolocomotion and anxiety-like behavior. A Experimental design of LPS-CpdA in vivo study 1. B Total distance travelled, C time spent, and D number of entries made into open arms of the elevated-plus maze (EPM). E Total distance travelled, F time spent, and G number of entries in the light compartment of the light–dark box. Effect of GPR120 agonism on LPS-induced H Iba-1, I TNF-α, J IL-1β, and K IL-6 mRNA expression in the nucleus accumbens (NAc). n = 7–8/group. Mean ± SEM; *p ≤ 0.05, **p ≤ 0.01, ****p ≤ 0.0001