Fig. 6

Schematic summary. Prolonged hyperglycemia using the two-hit inflammatory model results in increased pro-inflammatory microglia, resulting in neuronal cell loss, vascular pathology, and fibrinogen deposition in PBS-treated FKN^KO mice (left panel). In addition, diabetic rAAV–mFKN treated FKN^KO mice (no FKN cleavage occurring) shows more or less neuroprotection, microglia activation, and vascular damage (middle panel). Intra-vitreal administration of rAAV–sFKN alleviates microglia activation, preventing vascular damage, fibrin(ogen) deposition, and neuronal loss in the diabetic FKN^KO retina (right panel)