Journal of Neuroinflammation

Table 4 Correlations between serum Th17-related cytokines and cognitive assessments

From: 27-hydroxycholesterol causes cognitive deficits by disturbing Th17/Treg balance and the related immune responses in mild cognitive impairment patients and C57BL/6J mice

Th17-related cytokines	MMSE		MoCA
Th17-related cytokines	r	p value	r	p value
IL-17A	− 0.202	0.045*	− 0.227	0.024*
IL-12p70	− 0.098	0.338	− 0.137	0.182
IL-23	− 0.036	0.730	− 0.018	0.861
GM-CSF	0.046	0.650	− 0.104	0.306
MIP-3α	− 0.231	0.022*	− 0.241	0.016*
TNF-α	− 0.144	0.154	− 0.151	0.133
IL-13	0.153	0.130	0.207	0.040*
IL-28A	0.023	0.823	0.053	0.598
TGF-β1	0.065	0.524	0.118	0.243
IL-2	− 0.013	0.899	− 0.040	0.697
IL-5	0.039	0.700	0.037	0.714
TNF-β	− 0.136	0.177	− 0.132	0.190
IL-6	0.002	0.984	− 0.010	0.922
IL-10	− 0.121	0.235	− 0.119	0.239
IFN-γ	− 0.084	0.406	− 0.085	0.402
IL-17F	− 0.069	0.511	− 0.113	0.284
IL-1β	0.023	0.823	0.044	0.668
IL-4	− 0.121	0.241	− 0.002	0.984
IL-21	− 0.001	0.995	0.051	0.618
IL-22	0.060	0.555	0.067	0.511

*p < 0.05. IL: Interleukin; GM-CSF: granulocyte–macrophage colony-stimulating factor; MIP-3α: macrophage inflammatory protein 3α; TNF-α: tumor necrosis factor-α; TGF-β1: transforming growth factor β1; IFN-γ: Interferon-γ; TNF-β: tumor necrosis factor-β

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ISSN: 1742-2094

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