27-hydroxycholesterol causes cognitive deficits by disturbing Th17/Treg balance and the related immune responses in mild cognitive impairment patients and C57BL/6J mice

Table 5 Logistic regression analysis between Th17-related cytokines and MCI risk

Th17-related cytokines	OR	95% CI	p value
IL-17A	1.430	1.097–1.865	0.008*
IL-12p70	9.644	1.954–47.604	0.005*
IL-23	1.002	0.996–1.008	0.554
GM-CSF	1.232	1.034–1.469	0.020*
MIP-3α	1.020	0.998–1.042	0.075
TNF-α	1.064	1.003–1.129	0.038*
IL-13	0.601	0.392–0.921	0.019*
IL-28A	0.986	0.966–1.007	0.195
TGF-β1	0.997	0.995–1.000	0.027*
IFN-γ	1.013	0.970–1.058	0.556
IL-2	0.981	0.928–1.037	0.503
IL-5	0.882	0.757–1.029	0.111
TNF-β	1.105	0.975–1.252	0.117
IL-6	1.048	0.998–1.101	0.062
IL-10	0.921	0.364–2.326	0.861
IL-17F	1.483	0.913–2.407	0.111
IL-1β	0.942	0.777–1.142	0.541
IL-4	1.007	0.928–1.091	0.873
IL-21	0.999	0.997–1.000	0.076
IL-22	1.000	0.998–1.001	0.774

*p < 0.05. IL: Interleukin; GM-CSF: granulocyte–macrophage colony-stimulating factor; MIP-3α: macrophage inflammatory protein 3α; TNF-α: tumor necrosis factor-α; TGF-β1: transforming growth factor β1; IFN-γ: Interferon-γ; TNF-β: tumor necrosis factor-β

ISSN: 1742-2094