Fig. 8

Survival of WT and α7nAChR^−/− mice injected with monocytes during LPS-induced endotoxemia. A Graphical representation of experimental setup. Recipient mice are either WT (part B) or α7nAChR^−/− (part C). Control mice were given LPS only, with no monocytes. B Survival curve and temperature graph of WT recipients receiving WT, α7nAChR^−/−, or no monocytes (control) intravenously before a sub-lethal intraperitoneal dose of LPS. 8–10-week-old WT male and female mice were used as recipients (n = 6/treatment group). C Survival curve and temperature graph of α7nAChR^−/− recipients receiving either WT or α7nAChR^−/− monocytes intravenously before a sub-lethal intraperitoneal dose of LPS. 8–10-week-old α7nAChR^−/− male and female mice were used as recipients (n = 9/treatment group). For survival curves, statistical significance was assessed by the Kaplan–Meier method. Temperature graphs report mean temperature and standard error.