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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity

Fig. 6

Depletion of IKKβ from CNS macrophages results in macrophagic and neuronal gene alterations in EAE. Summary of the RNA-seq results. A Volcano plot representation of the DEGs per comparison. Blue dots represent significant (Padj < 0.05) log2FoldChanges. The x-axis shows the normalized counts per gene and the y-axis shows the Log2FoldChange. B Heatmap of the most significant DEGs in the EAEFF_EAEKO group across all other groups. Values have been scaled (R package heatmaply [31]) for a better visualization. C PPI network of the most significant DEGs in the EAEFF_EAEKO group. Blue color nodes represent down-regulation of the gene while red color nodes represent upregulation

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Journal of Neuroinflammation

ISSN: 1742-2094