Fig. 2

Respiratory motor pattern from n = 24 in situ preparations 24 h after pellet implantation. A, B Representative recordings (from top to bottom) of the perfusion pressure (PP), integrated thoracic sympathetic chain (tSNA), vagal (VNA) and phrenic (PNA) nerve activity from preparations obtained from animals of the sham control group (black) or the E. coli-infected group (red). C–G Group data for the mean perfusion pressure (C); flow (D); integrated t-SNA (E); respiratory burst frequency (fR, F) and coefficient of variation for total respiratory cycle length (CV TTOT, G) from preparations obtained from sham controls and from E. coli-infected animals. H Comparison of cycle-triggered averages (CTA) of integrated vagal and phrenic activities of sham control (black dashed line) and E. coli (red line)-infected animals. The left panel highlights the changes (gray shaded areas) in the respiratory phase durations (TI = time of inspiration; TPI = time of post-inspiration (phase 1 expiration) and TE = time of expiration (phase 2 expiration)) in relation to the normalized respiratory cycle length