Fig. 1

Sepsis impairs meningeal lymphatic drainage function in aged mice. A The experimental timeline of LPS treatment, tracer injection into the cisterna magna, and tissue collection (sac). B Schematic diagram of the dura mater. transverse sinuses (TS), confluence of sinuses (COS). C Representative immunofluorescence images of OVA-647 accumulation in dCLNs. D Quantification of the fluorescence intensity of OVA-647 in the dCLNs, n = 6. E Representative immunoblot of Lyve-1 and Prox1 proteins in the meninges. F Quantification of Lyve-1 and Prox1 proteins in the meninges, n = 4. *P < 0.05, **P < 0.01. All data are expressed as the mean ± SD