Fig. 6

Improvement in meningeal lymphatics reduces sepsis-induced expression of disease-associated genes in aged mice. A Principal component (PC) analysis showing clustering of samples. B Volcano plots illustrate the number of significantly differentially expressed genes. C Heatmap representation of the top 20 most significantly upregulated and downregulated (FDR < 0.1) genes in the eGFP + LPS group vs. VEGF-C + LPS group. D KEGG pathway analysis of upregulated genes in the VEGF-C + LPS group compared to the eGFP + LPS group. E KEGG pathway analysis of downregulated genes in the VEGF-C + LPS group compared to the eGFP + LPS group