Fig. 6

Slice cultures recapitulate salient features of neuroinflammatory disease biology observed in patients. Publicly available transcriptomic data from patients with either ALS, FTD or HD were assessed for similarity to the transcriptomic platform data. A Pearson correlation (r) matrix indicates a high degree of correlation in transcriptomes from subsets of patients in each disease group with inflammatory biology. Non-inflammatory populations, or unaffected brain regions (HD) exhibit no correlation to platform or neuroinflammatory patient populations. B Conservation of the DAM gene signature between platform and patient data. Control patient populations show little to no change in these genes. C Conservation of astrocyte activation signature between platform and patient data. Control patient populations show little to no change in these genes. D Conservation of loss of neurotransmitter receptor gene expression between platform and patient data. Control patient populations show little to no change in these genes. Superscripts indicate data sources: 1 = [5] glial subpopulation, 2 = GSE13162 grn mutation carriers, 3 = GSE3790 caudate nucleus samples, 4 = [5] Other patient subpopulations, 2 = GSE13162 Sporadic FTD patients, 3 = GSE3790 Broca’s Area 9 samples