Fig. 1

Effects of maternal obesity on the thickness of cortex, the volume of hippocampus and the white matter development in offspring: thickness of infralimbic cortex (A), prelimbic cortex (B) and somatosensory cortex (C) were significantly less in the offspring of obese dams without difference in the anterior cingulate cortex thickness (D); an example of Cavalieri point counting application on 40-μm-thick sagittal Nissl-stained section of the hippocampus for measuring the volume of hippocampus. Thirty-six green points hit the area and were counted. Scale bar = 200 μm (E); hippocampus was significantly smaller in the offspring of obese dams (F); examples of myelin basic protein (MBP) stained fimbria in the offspring from obese dams (delineated with green color) (G) and control group (delineated with green color). Scale bar = 400 µm (H); significant lower density of MBP was observed in hippocampal fimbria in offspring from obese dams (I); no difference in the MBP density in external capsule was observed between the groups (J). *p < 0.05, **p < 0.01, (n = 6/group)