Table 1 Raw expression values from whole blood enriched monocytes

Monocyte (all clusters)

 Ly6c1

ns

ns

Lymphocyte antigen 6C

Involved in acetylcholine receptor signaling pathway

 Ly6c2

0.165

0.668

Lymphocyte antigen 6C

Involved in acetylcholine receptor signaling pathway

 Ccr2

0.217

0.81

CC motif chemokine receptor 2

Migration into tissue

Non-classical monocyte (all clusters)

 Cx3cr1

0.74

0.467

Growth Factor Independent 1 Transcriptional Repressor

Non-classical monocytes

 Spn

0.762

0.26

Sialophorin

Alternative macrophage marker

 Cebpb

0.959

0.902

CCAAT Enhancer Binding Protein Beta

TF for conversion of classical monocytes into non-classical monocytes

 Klf2

0.86

0.511

KLF transcription factor 2

TF for conversion of classical monocytes into non-classical monocytes; pro-inflammation

 Pou2f2

0.948

0.64

POU Class 2 Homeobox 2

Marker non-classical monocytes

 Nr4a1

0.873

0.44

Nuclear receptor subfamily 4 group A

TF for conversion of classical monocytes into non-classical monocytes

 Adgre4

0.834

0.378

Adhesion G protein-coupled receptor E4

Novel marker for non-classical

Azurophilic granules (C9)

 Elane

0.39

14.02

Neutrophil elastase

Neutrophil granule serine protease, elastase

 Prtn3

19.62

60.28

Proteinase 3

Serine protease enzyme in neutrophil granules

 Ctsg

1.86

27.1

Cathepsin G

Serine protease enzyme in neutrophil granules

 MPO

0.45

14.49

Myeloperoxidase

Neutrophil-specific granules (all clusters)

 Mmp8

0.114

0.517

Matrix metalloproteinase-8

Neutrophil collagenase

 Lyz2

0.982

0.996

Lysozyme

Neutrophil lineage gene

 Lcn2

0.098

0.34

Lipocalin

Neutrophil gelatinase-associated lipocalin (NGAL)

Inflammation-associated (all clusters)

 Nfkbia

0.882

0.644

Nuclear factor-kappa-B-inhibitor alpha

Produces alpha subunit of Ikk protein complex

 Nfkbiz

0.778

0.383

IkappaB-zeta

Transcriptional regulator for NF-kappaB

 Il1b

0.523

0.054

Interleukin-1 beta

Pro-inflammatory immune response

 Tgfbi

0.583

0.905

Transforming growth factor beta-induced

Immunosuppressive

 Marco

0.326

0.007

Macrophage receptor with collagenous

Pattern recognition receptor; recognition and clearance of pathogens