Fig. 1

Adjusted associations between CSF IL-6 and NBD total score. Partial regression plots with results from the entire cohort and age-stratified cohorts of former American football players, adjusted for covariates: age, BMI, race, total AUDIT score, APOE-ε4 carrier, revised Framingham Stroke Risk Profile score, and sleep apnea. Regression results were: β: 0.286, 95%: CI 0.120–0.452, FDR-p: 0.005 (entire cohort), β: 0.247, 95% CI: 0.013–0.481, FDR-p: 0.156 (age < 60), β: 0.366, 95% CI: 0.089–0.642, FDR-p: 0.126 (age ≥ 60)