Inflammatory biomarkers for neurobehavioral dysregulation in former American football players: findings from the DIAGNOSE CTE Research Project

Table 3 Associations between CSF IL-6 and NBD factor scores

CSF IL-6 (log)	β (95% CI)	uncorr-p	FDR-p
Entire cohort
Explosivity	0.170 (− 0.001–0.341)	0.051	0.294
Emotional dyscontrol	0.240 (0.068–0.413)	0.007**	0.041*
Affective lability	0.276 (0.107–0.446)	0.002**	0.012*
Impulsivity	0.294 (0.128–0.460)	0.0006***	0.004**
NBD total	0.286 (0.120–0.452)	0.0009***	0.005**
Age < 60
Explosivity	0.130 (− 0.115–0.376)	0.293	0.455
Emotional dyscontrol	0.184 (− 0.058–0.425)	0.133	0.336
Affective lability	0.286 (0.063–0.509)	0.013*	0.156
Impulsivity	0.245 (0.007–0.482)	0.043*	0.153
NBD total	0.247 (0.013–0.481)	0.039*	0.156
Age ≥ 60
Explosivity	0.247 (− 0.033–0.527)	0.083	0.455
Emotional dyscontrol	0.357 (0.066–0.648)	0.018*	0.106
Affective lability	0.191 (− 0.122–0.504)	0.225	0.959
Impulsivity	0.421 (0.153–0.690)	0.003**	0.017*
NBD total	0.366 (0.089–0.642)	0.011*	0.126

Results from multivariate linear regression models between cerebrospinal (CSF) concentrations of Interleukin (IL)-6 (log-transformed) and neurobehavioral dysregulation (NBD) factor scores, within the entire cohort and age-stratified cohorts of former American football players. Models included covariates: age, BMI, race, total AUDIT score, APOE-ε4 carrier, revised Framingham Stroke Risk Profile score, and sleep apnea. Results are presented as standardized beta (β), with uncorrected and FDR-corrected p-values. * = p-values ≤ 0.05, ** = p-values ≤ 0.01, *** = p-value ≤ 0.001

ISSN: 1742-2094