Skip to main content

Table 5 Associations between biomarkers of interest and cognition

From: Inflammatory biomarkers for neurobehavioral dysregulation in former American football players: findings from the DIAGNOSE CTE Research Project

 

β (95% CI)

uncorr-p

FDR-p

CSF IL-6

Entire cohort

Verbal memory

− 0.101 (− 0.290 to 0.087)

0.288

0.576

Executive + speed

− 0.069 (− 0.236 to 0.097)

0.410

0.547

Age ≥ 60

Verbal memory

− 0.045 (− 0.402 to 0.311)

0.798

0.798

Executive + speed

− 0.164 (− 0.432 to 0.105)

0.225

0.450

CSF CRP

Age ≥ 60

Verbal memory

0.187 (− 0.144 to 0.518)

0.260

0.576

Executive + speed

0.027 (− 0.229 to 0.284)

0.830

0.830

Plasma NfL

Age ≥ 60

Verbal memory

0.082 (− 0.212 to 0.375)

0.581

0.775

Executive + speed

− 0.313 (− 0.540 to − 0.086)

0.008**

0.032*

  1. Sensitivity analyses: results from multivariate linear regression models between concentrations of log-transformed biomarker concentration of interest and cognitive factor scores; Verbal Memory and Executive Functioning and Processing Speed. Models were performed within cohorts of interest, based on previous significance with NBD factor scores. Models included covariates: age, BMI, race, total AUDIT score, APOE-ε4 carrier, revised Framingham Stroke Risk Profile score, sleep apnea, and years of education. Results are presented as standardized beta (β), with uncorrected and FDR-corrected p-values
  2. * = p-values ≤ 0.05, ** = p-values ≤ 0.01
Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094