Table 1 Summary of donor information
From: Advanced patient-specific microglia cell models for pre-clinical studies in Alzheimer’s disease
Study cohorts | Young healthy control | Healthy control (HC) | Alzheimer’s disease (AD) | |
|---|---|---|---|---|
N° of participants | n = 5 | n = 16 | n = 16 | |
Sex of participants | Females (%) | 40% (2/5) | 50% (8/16) | 43.8% (7/16) |
Males (%) | 60% (3/5) | 50% (8/16) | 56.3% (9/16) | |
Age of participants (mean ± SD) | 34.2 ± 9.6 | 67.7 ± 2.8 | 67.8 ± 6.6 | |
APOE genotype | E3/E3 (%) | N/A | 31.3% (5/16) | 18.8% (3/16) |
E3/E4 (%) | 56.3% (9/16) | 62.5% (10/16) | ||
E4/E4 (%) | 12.5% (2/16) | 18.8% (3/16) | ||
Brain Aβ burden | Low (%) | N/A | N/A | 6.3 (1/16) |
High (%) | 37.5 (6/16) | |||
Very high (%) | 56.25 (9/16) | |||
Clinical consensus | AD (%) | N/A | N/A | 68.8 (11/16) |
Mild cognitive impairment (MCI) (%) | 6.3 (1/16) | |||
MCI with AD pathology (%) | 25 (4/16) | |||