Table 1 The association between antihistamines and LEDD
Antihistamine | Exposed case | Antihistamine-unexposed group | Antihistamine-exposed group | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
LEDD | LEDD | Difference | Ratio | LEDD | LEDD | Difference | Ratio | p-value | ||
Before index | After index | Before index | After index | |||||||
Overall | 24,150 | 258.143 | 263.982 | 5.839 | 5.607 | 263.127 | 267.32 | 4.193 | 6.208 | 0.17 |
1st generation | 13,391 | 257.533 | 263.655 | 6.122 | 5.63 | 272.614 | 276.255 | 3.641 | 4.919 | 0.369 |
Chlorpheniramine | 4832 | 256.555 | 260.456 | 3.901 | 4.575 | 289.544 | 290.461 | 0.916 | 3.35 | 0.011* |
Clemastine | 28 | 245.797 | 252.404 | 6.607 | 5.828 | 260.051 | 254.51 | -5.54 | 0.833 | 0.378 |
Dimenhydrinate | 6481 | 256.032 | 263.127 | 7.095 | 6.042 | 251.093 | 257.03 | 5.937 | 6.821 | 0.127 |
Hydroxyzine | 2050 | 256.758 | 261.798 | 5.04 | 3.935 | 271.368 | 271.564 | 0.196 | 2.748 | 0.051 |
2nd generation | 10,759 | 257.571 | 263.582 | 6.011 | 5.586 | 253.639 | 258.385 | 4.745 | 7.497 | 0.09 |
Azelastine | 1098 | 258.29 | 264.081 | 5.791 | 5.807 | 280.206 | 284.477 | 4.271 | 4.977 | 0.681 |
Bepotastine | 2086 | 256.223 | 263.149 | 6.926 | 6.328 | 252.281 | 256.457 | 4.176 | 5.229 | 0.243 |
Cetirizine | 1685 | 261.267 | 267.499 | 6.232 | 5.422 | 268.424 | 273.625 | 5.201 | 6.118 | 0.492 |
Desloratadine | 65 | 262.288 | 272.612 | 10.323 | 6.893 | 247.033 | 238.168 | -8.865 | 3.057 | 0.341 |
Ebastine | 599 | 260.882 | 267.265 | 6.383 | 6.278 | 260.019 | 272.092 | 12.073 | 9.224 | 0.088 |
Fexofenadine | 1356 | 253.307 | 266.844 | 13.537 | 9.399 | 253.276 | 258.86 | 5.584 | 6.997 | 0.045* |
Ketotifen | 147 | 258.036 | 259.198 | 1.163 | 4.706 | 264.295 | 276.573 | 12.279 | 9.575 | 0.162 |
Levocetirizine | 2384 | 257.333 | 269.701 | 12.373 | 8.309 | 258.232 | 263.3 | 5.068 | 6.35 | 0.046* |
Loratadine | 374 | 266.108 | 273.866 | -7.758 | 5.128 | 261.734 | 256.611 | -5.124 | 2.15 | 0.087 |
Olopatadine | 965 | 259.044 | 268.828 | 9.784 | 8.341 | 209.294 | 235.14 | 25.846 | 27.218 | < 0.001*** |