Fig. 4

The SCI-specific gene response links to immunosuppression within the blood. A and B Number of differentially expressed genes (DEGs) up- (A) or down- (B) regulated between blood samples. Coloured parts of Venn diagram indicate SCI-specific genes (i.e., those regulated in the same direction by SCI compared to sham and/or naïve samples, but not between sham v naïve). C Unique statistically enriched gene ontology (GO) terms for the SCI-specific gene set. GO terms are split based on whether they were regulated in SCI compared to either sham, naïve, or both. D Number of gene markers (i.e., DEGs; left) and GO terms (right) regulated in each cell cluster following SCI compared to both sham and naïve controls. E Top GO terms between clusters for genes regulated in SCI compared to both sham and naïve conditions. Red colour in GO plots represents –log10(adjusted p-value) for upregulated genes/terms, and blue colour the log10(adjusted p-value) for downregulated genes/terms; dot size represents ratio of genes contributing to the GO term