Fig. 6

Congruence of the SCI-specific gene signature identified in huNSG-SGM3 mice with that of human patients. A Experimental workflow for the reference human patient dataset [2]. B Venn diagram showing the genes up- (left) and downregulated (right) in trauma control (TC) v healthy control (HC), spinal cord injury (SCI) v HC, and SCI v TC comparisons in the reference dataset. Coloured parts of venn diagram indicate the SCI-specific genes. C Table showing the number of SCI-specific genes in the human dataset from Kyritsis et al. [2] (row 1), their overall presence within the humanised mouse dataset (row 2), the number of SCI-specific (i.e. regulated) genes in the humanised mouse dataset (row 3), and the number of human SCI-specific genes that overlap with the huMice SCI-specific genes (row 4). D The 5 gene ontology (GO) terms linked to the 21 overlapping downregulated genes identified in C. Driver genes regulating these GO terms are shown on the x-axis