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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: SPOCK2 modulates neuropathic pain by interacting with MT1-MMP to regulate astrocytic MMP-2 activation in rats with chronic constriction injury

Fig. 3

SPOCK2 downregulation alleviates CCI-induced NP. A Decreased expression level of SPOCK2 after i.t. injection of SPOCK2-shRNA in rats spinal cord after CCI-induced NP. (*P < 0.05 vs CCI + shScr). B i.t. injection of SPOCK2-shRNA 3 days prior to the beginning of CCI increased PWT and PWL at 7 and 14 days after CCI (*P < 0.05 vs CCI + shScr). C Western blot analysis showing the knockdown efficacy of SPOCK2-siRNA (*P < 0.05 vs naïve). D Immunofluorescence showing decreased SPOCK2 expression in the dorsal horn after i.t. injection of SPOCK2-siRNA (Scale 50 um). E Continuous i.t. injection of SPOCK2-siRNA for 5 days (from CCI 3 days to 7 days) increased PWT and PWL at 7 and 14 days after CCI (*P < 0.05 vs CCI + NC-siRNA)

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Journal of Neuroinflammation

ISSN: 1742-2094