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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: SPOCK2 modulates neuropathic pain by interacting with MT1-MMP to regulate astrocytic MMP-2 activation in rats with chronic constriction injury

Fig. 5

RNAi-mediated SPOCK2 downregulation in CCI rats reduces astrocytic activation, ERK1/2 activation and IL-1β production. A Double staining showing decreased (**P < 0.01 vs CCI + NC-siRNA) colocalization of SPOCK2 with GFAP after i.t. injection of SPOCK2-siRNA (Scale 50 um). B Decreased expression ratio of p-ERK/ERK after i.t. injection of SPOCK2-siRNA. (**P < 0.01 vs CCI + NC-siRNA). The expression ratio changes of p-JNK/JNK were not significant (P > 0.05 vs CCI + NC-siRNA) after i.t. injection of SPOCK2-siRNA. C Decreased expression level of IL-1β after i.t. injection of SPOCK2-siRNA. (**P < 0.01 vs CCI + NC-siRNA). The change in expression of CCL2 was not significant (P > 0.05 vs CCI + NC-siRNA) after i.t. injection of SPOCK2-siRNA

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Journal of Neuroinflammation

ISSN: 1742-2094