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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: TYROBP/DAP12 knockout in Huntington’s disease Q175 mice cell-autonomously decreases microglial expression of disease-associated genes and non-cell-autonomously mitigates astrogliosis and motor deterioration

Fig. 1

TYROBP network is upregulated in HD brains. STRING-generated interaction network of the common differentially expressed genes (DEGs) detected by RNA-seq in HD brains. STRING v11.5 was used to derive the network of 221 DEGs applying following prediction methods: text mining, experiments, databases, co-expression, neighborhood, gene fusion, co-occurrence. The nodes that did not interact with other nodes were deleted. The blue nodes illustrate genes/proteins assigned to “immune system process” Gene Ontology pathway. Line thickness indicates the strength of data support. Interaction score > 0.7

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Journal of Neuroinflammation

ISSN: 1742-2094